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Polycystic Ovarian Syndrome PCOS is one of the most casinorpg real money and, consequently, mistreated disease states in medicine.

PCOS is actually a subgroup casinorpg real money in the much larger disorder of androgen casinorpg real money overproduction. Androgens are male hormones that every woman produces, though generally in levels much lower than those produced by a man. Women produce androgens in the adrenal glands and in the ovaries. These signs include oily skin, acne, hirsutism casinorpg real money hair growthirregular and occasionally heavy menses, and often sub-fertility or infertility secondary to excess androgens interfering with ovulations.

In PCOS, the source of the overproduction of androgens is the ovaries. While there are several mechanisms that can cause the ovaries to overproduce androgens, including an enzyme defect or a tumor, PCOS is one of the more common causes. In the ovary there are several different types of cells. Some of the cells theca cells and interstitial cells produce testosterone when stimulated by LH or insulin.

Other ovarian cells granulosa cells absorb the testosterone and convert it to the estrogen, estradiol, under the influence of the enzyme aromatase. Please click for source is a normal, physiologic activity in the ovary and is how the ovary produces estrogens.

High levels of testosterone in the ovary shut down the activity of the aromatase enzyme that casinorpg real money the testosterone to estradiol.

These high testosterone levels can be caused by a number of sources. These casinorpg real money include overproduction by the adrenal glands, with the elevated levels of testosterone being released into the bloodstream in high enough levels that the aromatase enzyme activity in the ovary is shut down.

This then permits the testosterone being produced at a normal rate by the theca and interstitial cells of the ovary to build up and then directly shut down aromatase enzyme activity in the ovary.

The excess testosterone produced in the ovary continue reading casinorpg real money out of the ovary and into the bloodstream and general circulation. In addition to creating the physical signs click a testosterone excess noted above, the elevated levels of circulating testosterone are then converted to estrogen by other tissues of the body including fat, liver, skin, and brain tissue.

This results in higher than normal casinorpg real money of estrogen for these individuals in the brain which, in turn, stimulates the casinorpg real money gland to release higher concentrations of the ovarian stimulating read more LH leutinizing hormone. These elevated levels of Casinorpg real money then directly stimulate the theca and stromal casinorpg real money of the ovary to produce even higher levels of testosterone, continuing casinorpg real money shutdown of the aromatase enzyme.

A self-perpetuating, vicious circle is then established. The high local levels of article source also lock follicle and egg development in the preantral phase at 10 to 12 mm in diameter.

Ovulation does not occur, which leads to casinorpg real money irregular menses, prolonged and heavy menses click at this page menstrual bleeding does occur, and infertility. Insulin resistance, with elevated levels of insulin needed to maintain normal blood sugar levels, can also cause the ovaries to overproduce testosterone.

This occurs because insulin, along with LH, has the ability to directly stimulate the theca and interstitial cells to produce testosterone. With increased production of testosterone by the cells in the ovaries under the influence of insulin the effect on the aromatase enzyme is the same. The aromatase enzyme shuts down and stops converting the testosterone in the ovary to estrogen.

Therefore, while the clinical pictures of these 2 conditions can this web page similar, the actual disease mechanism is significantly different. The best treatment results are achieved when the etiology of the ovarian androgen overproduction is determined and treated directly. Skip to content Polycystic Http:// Syndrome PCOS is one of the most misunderstood and, consequently, mistreated disease states in medicine.

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